Viropil
Rated 5.00 out of 5 based on 12 customer ratings
(12 customer reviews)
Product Name | Viropil |
Dose/Strength | 50 mg/ 300mg/ 300mg |
Packaging Size | 30 Tablets |
Brand | |
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Salt |
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Category: Meds for HIV
Description
Viropil (Dolutegravir + Lamivudine + TDF)
Viropil is the combination of three protein inhibitors dolutegravir 50 mg, lamivudine 300 mg and tenofovir disoproxil fumarate (TDF) 300 mg indicated in patients with HIV-1 infection. Among these, dolutegravir inhibits the process of synthesis of genetic material (DNA through integrase strand transfer).
Whereas, lamivudine and TDF replace other proteins in the reaction, hindering the process of replication.
Viropil (Dolutegravir + Lamivudine + TDF) is administered as a complete regimen in HIV-1 patients weighing at least 40 kgs. The tablet is taken in the form of oral dosage on an empty stomach once daily. As Viropil (Dolutegravir + Lamivudine + TDF) is an FDC, it’s dosing cannot be adjusted.
Hence, in patients with severe renal (kidney) impairment or end-stage kidney disease requiring hemodialysis, the triple-drug combo is not recommended.
Other characteristics of this tablet:
Characteristics | Dolutegravir 50 mg | Lamivudine 300 mg | TDF 300 mg |
Absorption in the system | 2 to 3 hours | – | 1 hour and 40 minutes |
Binding with viral cells | Binding affinity- 98.9% | Binding affinity- 99.5 to 99.7% | Binding affinity- 0.7 to 7.2% |
Bioavailability | – | 80 to 87% | 25% |
Time for disposing of 50% of drug | 14 hours | 5 to 7 hours | 17 hours |
When should it be avoided or used cautiously:
Drug interactions: The FDC drug might interact with other drugs, it is crucial to inform the doctor about those medicines.
Allergic (hypersensitivity) reactions: There are chances of developing skin rashes, hence patients need to immediately stop the drug if they are seen with symptoms like fever, illness, extreme tiredness, pain in thetab muscles or joints, skin peeling, oral blisters and lesions, inflammation in eyes, swelling of face, lips, tongue or mouth and difficulty in breathing (dyspnea).
Lactic acidosis: If patients procure symptoms like nausea, vomiting, unusual discomfort in the stomach and weakness, causing excessive production of lactic acid in the blood. In such cases, it should be immediately discontinued.
Patients with Hepatitis B or C coinfection: Such patients should not discontinue the drug in the middle of the cycle as it might cause serious problems related to Hepatitis B viral infection.
Pancreatitis: Monitor any signs of pancreatitis (inflammation of the pancreas) especially in children including symptoms like severe pain in the upper part of the stomach-region with or without nausea and vomiting.
Immune reconstitution syndrome: These conditions occur when patients witness any signs of inflammation from previous infections after starting this tablet.
Lactation: It is not recommended in patients who are breastfeeding
Side-effects:
Most common side-effects:
- Sleeping problems (insomnia)
- Tiredness (Fatigue)
- Headache
- Skin rashes
- Depression
- Diarrhea
- Nausea
- Generalized pain
Other side-effects:
Side-effects associated with liver problems | Side-effects associated with kidney problems |
Jaundice (white part of skin or eyes turning yellow) | Pain in the bones |
Loss of appetite | Pain in the arms, legs, or feet |
Nausea or vomiting | Broken (fractured) bones |
Pain in the right side of the stomach region | Muscle pain |
Dark-coloured urine | Weakness |
Note: Viropil (Dolutegravir + Lamivudine + TDF) might depict other side-effects too, get in touch with your healthcare provider for more info.
FAQs for Viropil
Viropil is a combination of antiretroviral medicines prescribed for HIV.
It is manufactured by Emcure Pharmaceuticals Ltd.
The active ingredients of Viropil include Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate. It is a triple drug combination.
It is made up of 50mg of Dolutegravir and 300 mg each of Lamivudine and Tenofovir disoproxil fumarate.
Yes. Lamivudine and Tenofovir Disoproxil Fumarate are used in the creation of drugs that fight chronic Hepatitis B infection. Dolutegravir is exclusively used in making drugs for fighting HIV.
It boosts the immunity of the body against HIV and manages AIDS or acquired immunodeficiency syndrome. It restricts the growth of HIV by preventing the action of reverse transcriptase enzyme and reduces the risk of HIV-related complications, thus increasing the infected individual’s lifespan.
It is sold in a pack of 30 tablets.
It should be stored at room temperature below 30° C. The drug should not be exposed to direct heat or light lest it affects its efficacy.
The tablets have to be taken in the dose and duration as advised by the doctor. The pills have to be swallowed whole and should not be chewed, crushed, or broken. The dosage should not be missed as it affects the recovery of the patient. The patient should take the tablets till the completion of the course. The course should not be stopped midway, as it will hamper its efficacy.
Yes. Patients have to consult with their doctors before taking the tablet if they are alcoholic. If the patient is being treated for severe liver disease, this tablet has to be used cautiously and at the doctor’s discretion for dose adjustment.
The common side effects of taking it include fever, headache, joint pain, vomiting, weakness, insomnia, fever, abdominal pain, indigestion, diarrhea, and back pain.
Yes. It interacts with other drugs. These interactions could sometimes cause adverse reactions. Therefore, a doctor’s advice has to be sought before combining it with other medications.
One of the side effects of this tablet intake is weakened bones. This is because this tablet intake can cause a reduction in calcium levels in the patient’s body. Therefore, the patient should get their calcium and Vitamin D levels checked regularly.
No. It is a combination of three drugs designed against HIV. Therefore, Viropil itself can be used only against HIV.
It can cause severe infections related to Hepatitis B infection if the patient has a Hepatitis B or C coinfection. There is also the possibility of developing pancreatitis or the inflammation of the pancreas, especially in children. It can also give way to Immune reconstitution syndrome, where patients may witness signs of inflammation from previous infections.
It should not be used during pregnancy as it could be risky for the developing baby. However, doctors will prescribe the tablets in certain life-threatening situations where the benefits outweigh the costs. Therefore, the doctor must be informed about the pregnancy or plan to conceive before taking the tablets.
It is not sure whether this tablet has an impact on the motor coordination skills of the patients. However, if the patient experiences signs of fever or headache, they should not drive until the signs subside.
Yes. Patients who develop skin rashes, skin peeling, inflammation, swelling in the face, mouth, and lips, and difficulty breathing should discontinue the drug immediately. If patients produce excess lactic acid in the blood after taking the tablet, they should discontinue it immediately.
Patients with end-stage kidney disease that requires hemodialysis or have severe renal impairment should discontinue this tablet.
Yes. Common side effects of it seen in kidney patients include bone pain, pain in the arms, feet, and legs, muscle pain, weakness, and fractured bones.
Yes. Common side effects of it seen in liver patients include jaundice, nausea, vomiting, dark-colored urine, and pain in the right side of the stomach region.
No. The dosage of Viropil cannot be changed at the patient’s will. Suppose the patient is suffering from particular conditions or experiences adverse symptoms during the course. In that case, doctors can advise patients to stop taking the drug.
It is purchased directly from the manufacturer without the help of intermediaries. The tablets are handled in strict compliance with medical regulations. The packing and packaging are done to endure international travel and prevent external factors like direct heat, light, and humidity from impacting the efficiency of this tablet.
No. There are no substitute brands for Viropil.
Yes. Once patients know that they are HIV-positive, they should always stick to the prescribed course of Viropil. They should not share their personal belongings like razors with others to prevent the spread of HIV. Patients can have safe sex while taking it to decrease the chances of HIV spreading to others.
Reviews (12)
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The Site may contain health- or medical-related materials or discussions regarding sexually explicit disease states. If you find these materials offensive, you may not want to use our Site. The Site and its Content are provided on an "as is" basis.
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Links to educational content not created by Gandhi Medicos are taken at your own risk. Gandhi Medicos is not responsible for the claims of external websites and education companies.
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General Advisory:We advise you to stick to medication routine (or medication adherence), i.e. to take medications as prescribed – the right dose, at the right time, in the right way and frequency. Not taking medicines as prescribed by a doctor or instructed by a pharmacist could lead to disease getting worse, hospitalization, even death.
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Sean Flynn –
Most trusted medicine for the treatment of HIV.
Barry McKay –
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