Dolutegravir + Lamivudine + Tenofovir Disoproxil Fumarate

Dolutegravir -50mg

Lamivudine -300mg

Tenofovir disoproxil fumarate -300mg

Classification - HIV Medicine

Why are dolutegravir, lamivudine, and tenofovir disoproxil fumarate combined into a single tablet?

The combination makes administration easier.

It also offers synergistic effects to suppress HIV.

Uses of Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablet-

It is used in HIV infections.

Dolutegravir, lamivudine, and tenofovir disoproxil fumarate working-

It blocks viral replication at multiple stages.

Dolutegravir- It prevents genetic changes in human cells.

Lamivudine - It inhibits the formation of viral DNA in cells.

Tenofovir - It inhibits viral cell multiplication.

The benefits of using dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablet -

Powerful control of HIV

Well tolerated,

Lowers the risk of drug resistance

Fewer side-effects

Improves immunity

Prevent transmission

Prevents HIV progression

What are the side effects?

Common side effects

Insomnia

Tiredness

Headache

Increased weight

Skin rashes

Abdominal pain

Nausea

Diarrhea

Hyperlipidemia

Serious side effects

Liver dysfunction

Lactic acidosis

Increased blood glucose

Kidney dysfunctions

Neurological side effects - depression / suicidal thoughts

Bone density loss

Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablet precautions -

Do not stop medication immediately.

As it may flare up the previous hepatitis infection.

Use it carefully in -

Diabetes

Liver disorders

Mental health

Elderly

Kidney impairment

Pregnant women

Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablet drug interactions-

It must be completely avoided with Dofetilide.

It must be carefully used with -

Antacids

Rifampicin

Phenytoin

Barbiturates

Metformin

Supplements containing Iron or calcium

What are dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablet warnings?

To be used under medical prescription.

It must be avoided in -

Severe liver dysfunction

Severe renal impairment

Hypersensitivity or allergy to drug components.

Breastfeeding mothers

Co-administration with nephrotoxic drugs

Important Monitoring Considerations -

Long-term use of dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablet must be checked for -

Liver function - elevated liver enzymes

Viral loads (HIV, HBV)

Bone loss

Neurological conditions

Renal functions

Blood glucose

Weight

CD4+ count

Gandhi Medicos: 19 years of legacy in HIV care

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