Dacarbazine

Classification - Anticancer Medicine

What is Dacarbazine?

It is a component of a chemotherapy which used against various cancers and solid tumors.

Top selling Dacarbazine - Dasakast

Uses of Dacarbazine

Myeloid Leukemia (Chronic)

Lymphoblastic leukemia (Acute)

Working of Dacarbazine ?

It inhibits kinase enzymes and certain proteins.

Slows down or stops the cancer cell growth.

Common side effects

Fluid retention

Lowering of blood count

Nausea

Diarrhea

Skin ulcers and rashes

Serious side-effects

Risk of cardiac arrhythmia

Bone marrow suppression

Pulmonary Arterial Hypertension

Contraindications

Not to be used in patients-

Hypersensitivity or allergic reaction to the drug or its excipients.

Breastfeeding mothers

Pregnant women

Precautions

To be cautiously used in patients with -

Bleeding disorder

Heart diseases

Liver disorder

Kidney impairment

Recent surgery or wound

Disorders of the stomach

Toxicities

Bone Marrow suppression - low blood count

Pleural effusion- shortness of breath, fluid buildup around the lungs

Hematological toxicity -bleeding risk, decreased platelet count

Hepatotoxicity - elevated enzymes

QT Prolongation- irregular heartbeats

Warnings

Prescription drug to be used under medical supervision

Important safety and monitoring information

Dacarbazine requires regular monitoring for hematological functions, blood pressure, liver functions, ECG, regular monitoring of electrolytes.

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