Active Chemical Molecule

Daclatasvir and sofosbuvir

Classification - Hepatitis C medicines

Daclatasvir and Sofosbuvir combination?

It is a combination of 2 direct-acting antivirals, effectively used against the Hepatitis C virus.

Uses of Daclatasvir and sofosbuvir

Chronic Hepatitis C
Hepatitis C co-infected with HIV

Working of Daclatasvir and sofosbuvir combination-

Sofosbuvir, stops the viral DNA from producing its copies (replication).
Daclatasvir stops viral multiplication and assembly.

Benefits -

Reduces viral load within 12 weeks.
Has a broad spectrum of activity against all genotypes.
It can be used after a liver transplant.
Can be used in HIV co-infections.
Can be used in cirrhosis (compensated /decompensated).

Common Side Effects

Nausea
Dizziness
Headache
Digestive issues
Tiredness
Diarrhea

Serious side effects

Severe Bradycardia (when taken with amiodarone)
In Hepatitis B co-infections - Hepatitis B flare-ups
Risk of liver failure.
Severe drop in red blood count.

Precautions

To be used cautiously in patients
Kidney disorders
Liver disorder
Hepatitis B co-infections
When used in combination with ribavirin and amiodarone

Contraindications

Allergy or hypersensitivity to Daclatasvir, sofosbuvir, or any other drug component.
Breastfeeding mothers
Pregnant women

Warning

To be taken when prescribed by the doctor.

Important Safety and Monitoring Information

Regular monitoring of liver functions,
Kidney functions,
Heart functions,
Co-infections,
Drug interactions - Ribavirin and Amiodarone
Not to be used as monotherapy for HCV infections.

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