Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg
Composition-
- Dolutegravir (50mg)
- Emtricitabine (200mg)
- Tenofovir Alafenamide (25mg)
- Classification - HIV Medicine
Dolutegravir, Emtricitabine, Tenofovir Alafenamide ?
It is widely used as a single-dose regimen against HIV infection that offers better patient compliance and a synergistic effect.
Uses -
- HIV -1 infections
How does it work?
Dolutegravir- It prevents genetic transmission into human immune cells (CD4+ T cells).
Emtricitabine - It inhibits viral cell multiplication.
Tenofovir Alafenamide - Stops the formation of viral cell copies.
Benefits
- Powerful control of HIV
- Well tolerated,
- Lowers the risk of drug resistance
- Fewer side-effects
- Improves immunity
- Prevent transmission
- Prevent HIV progression
Common side effects
- Insomnia
- Tiredness
- Headache
- Increased weight
- Dermatological side effects
- Nausea
- Diarrhea
- High levels of cholesterol
Serious side effects
- Liver dysfunction
- Lactic acidosis
- Increased blood glucose
- Kidney dysfunctions
- Neurological side effects - depression / suicidal thoughts
Precautions:
- To be used cautiously in
- People with diabetes
- Liver disorders
- Mental health
- Pregnant women
Drug interactions
- Antacids
- Rifampicin
- Phenytoin
- Efavirenz
- Barbiturates
- Metformin
- Iron/calcium supplements
Contraindications
- Severe liver dysfunction.
- Severe renal impairment
- Hypersensitivity or allergy to drug components.
- Children under 4 weeks or less than 3kg.
Warnings
- To be used under medical prescription
- Stop treatment by tapering the dose in Hepatitis co-infections
Important Monitoring Considerations
- Check for -
- Liver function - elevated liver enzymes
- Viral loads (HIV, HBV)
- Neurological conditions
- CD4 cell count
- Renal functions
- Blood glucose
- Weight
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Formulations based on "Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg" (2)
Spegra 90 Tablets
Dolutegravir + Emtricitabine + Tenofovir Alafenamide
It is manufactured by Emcure pharmaceutical.
Spegra 30 Tablets / 90 Tablets
Dolutegravir + Emtricitabine + Tenofovir Alafenamide
The Spegra (Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)) tablets do not cure HIV, rather it slows down the growth of the virus in the body. It is a combination drug u...