Composition-
Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg
Classification: HIV Medicine
Dolutegravir, Emtricitabine, Tenofovir Alafenamide?
It is widely used as a single-dose regimen against HIV infection that offers better patient compliance and a synergistic effect.
Uses
- • HIV -1 infections
How does it work?
- • Dolutegravir – It prevents genetic transmission into human immune cells (CD4+ T cells).
- • Emtricitabine – It inhibits viral cell multiplication.
- • Tenofovir Alafenamide – Stops the formation of viral cell copies.
Benefits
- • Powerful control of HIV
- • Well tolerated
- • Lowers the risk of drug resistance
- • Fewer side-effects
- • Improves immunity
- • Prevent transmission
- • Prevent HIV progression
Common Side Effects
- • Insomnia
- • Tiredness
- • Headache
- • Increased weight
- • Dermatological side effects
- • Nausea
- • Diarrhea
- • High levels of cholesterol
Serious Side Effects
- • Liver dysfunction
- • Lactic acidosis
- • Increased blood glucose
- • Kidney dysfunctions
- • Neurological side effects – depression / suicidal thoughts
Precautions
To be used cautiously in
- • People with diabetes
- • Liver disorders
- • Mental health
- • Pregnant women
Drug Interactions
- • Antacids
- • Rifampicin
- • Phenytoin
- • Efavirenz
- • Barbiturates
- • Metformin
- • Iron/calcium supplements
Contraindications
- • Severe liver dysfunction
- • Severe renal impairment
- • Hypersensitivity or allergy to drug components
- • Children under 4 weeks or less than 3kg
Warnings
- • To be used under medical prescription
- • Stop treatment by tapering the dose in Hepatitis co-infections
Important Monitoring Considerations
Check for –
- • Liver function – elevated liver enzymes
- • Viral loads (HIV, HBV)
- • Neurological conditions
- • CD4 cell count
- • Renal functions
- • Blood glucose
- • Weight
Gandhi Medicos – Global Standard HIV Medicines
Gandhi Medicos is a 19-year-old trusted HIV medicine distributor and supplier, strengthening access to affordable, high-quality HIV treatments worldwide.
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Trusted by Doctors. Preferred by Patients.
Gandhi Medicos – Your Global HIV Care Partner
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