Doxorubicin Hydrochloride

Classification - Anticancer Medicines

Doxorubicin?

Doxorubicin is an anticancer medicine that kills viable cancer cells for various types of cancer.

Uses of Doxorubicin -

Blood cancers

Leukemia

Lymphocytic cancers

Breast cancer

Lung cancer

Sarcomas

Ovarian cancers

Working of Doxorubicin -

Blocks the enzyme topoisomerase 2

Inhibit cancer cell division and growth

Causes cancer cell death

Common side effects of Doxorubicin

GIT upset - Nausea, vomiting

Mouth and throat ulcers

Hair loss

Urine discoloration

Red eyes.

Serious Side-effects

Difficulty in breathing

Skin rash

Seizures

Red blood in stool and vomit

Toxicities

Doxorubicin causes dose-dependent toxicities

Cardiac toxicity

Myelosuppression

Severe local tissue necrosis

Contraindications

Allergy to the drug components

Breastfeeding mothers

Pregnant women

Precautions

To be used cautiously in patients with

Heart disease

Low blood count

Liver disease

Warnings

To be used under doctor's prescription as a slow intravenous infusion.

Important Safety and Monitoring Considerations

Regularly monitor-

Liver function,

Cardiac function, and

Total blood count

Gandhi Medicos -Advanced Anticancer Care

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