Efavirenz + Lamivudine

Classification - HIV medicine

What is Lamivudine?

It is an anti- HIV medicine widely used in combination as treatment for HIV infections and Hepatitis B infections.

Doctors' prescribed anticancer formulation - Lamipure

Uses of Lamivudine

Chronic Hepatitis B

First-line treatment for HIV infection

Working of Lamivudine-

It copies DNA bases and inhibits chain elongation.

Inhibits viral replication

Causes viral cell death

Benefits

Well tolerated

Widely used maintenance therapy for HIV

Double action - HIV and Hepatitis B

Improves liver function

Lowers viral load

Common side effects

Nasal congestion

Cough

Headache

Stomach pain

Indigestion- diarrhea, nausea

Tiredness

Muscle pain, joint pain

Sore throat

Serious side effects

Hepatomegaly - jaundice, yellowish urine

Lactic acidosis - breathing problems

Liver inflammation

Inflammation of the pancreas in children

Risk of severe infections

Allergic Reaction

Precautions

To be used cautiously in -

Liver diseases

Kidney impairment

Co-infections Hepatitis B

Pregnant and lactating women

Contraindications

Severe liver dysfunction.

Hypersensitivity or allergic reaction to the drug or its excipients.

Warnings

To be used under medical prescription.

Discontinuing immediately in Hepatitis B patients may cause serious hepatitis flare-ups.

Important Monitoring Considerations

Check for -

Lactic acidosis

Liver function - elevated liver enzymes

Viral loads (HIV, HBV)

Pancreatitis

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