Emtricitable-tenofovir-alafenamide

Classification -HIV Medicine

Emtricitabine -Tenofovir combination?

It is a fixed-dose combination used for HIV treatment, significantly lowering viral count.

Uses

HIV-1 treatment

HIV-1 prophylaxis

How does it work?

It inhibits the conversion of RNA to DNA.

Stops viral replication and multiplication.

Benefits

Significantly lowers viral load

Improves immunity

Inhibit transmission

Reduce the chances of developing resistance

Reduced kidney and bone side effects

Also effective against HBV, offering dual protection

Common side effects

Nausea

Weakness

GIT upset

Skin rashes

Lightheadedness

Serious side effects

Lactic acid buildup -shortness of breath

Fluid retention -swelling of legs

Inflammation in the liver

yellowish discoloration of urine or skin

Loss of bone mineral density

Anaphylaxis

Risk of infections

Kidney impairment

Precautions

To be used cautiously in -

Liver diseases

Kidney impairment

Co-infections Hepatitis b

Pregnant and lactating women

Contraindications

Severe liver dysfunction.

Severe kidney diseases

Hypersensitivity or allergy to drug components.

Warnings

To be used under medical prescription.

Do not discontinue abruptly in Hepatitis B patients - may cause serious liver flare-ups

Important Monitoring Considerations

Check for -

Lactic acidosis

Liver function - elevated liver enzymes

Kidney functions

Viral loads (HIV, HBV)

Bone health

Drug interactions

Anticonvulsant

Statins

Antifungals

Anti-tubercular

NSAIDs and other nephrology drugs

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