Emtricitabine-Tenofovir-Alafenamide

Classification – HIV Medicine

Emtricitabine –Tenofovir combination?

It is a fixed-dose combination used for HIV treatment, significantly lowering viral count.

Uses

  • • HIV-1 treatment
  • • HIV-1 prophylaxis

How does it work?

It inhibits the conversion of RNA to DNA. Stops viral replication and multiplication.

Benefits

  • • Significantly lowers viral load
  • • Improves immunity
  • • Inhibit transmission
  • • Reduce the chances of developing resistance
  • • Reduced kidney and bone side effects
  • • Also effective against HBV, offering dual protection

Common side effects

  • • Nausea
  • • Weakness
  • • GIT upset
  • • Skin rashes
  • • Lightheadedness

Serious side effects

  • • Lactic acid buildup – shortness of breath
  • • Fluid retention – swelling of legs
  • • Inflammation in the liver – yellowish discoloration of urine or skin
  • • Loss of bone mineral density
  • • Anaphylaxis
  • • Risk of infections
  • • Kidney impairment

Precautions

To be used cautiously in –

  • • Liver diseases
  • • Kidney impairment
  • • Co-infections Hepatitis B
  • • Pregnant and lactating women

Contraindications

  • • Severe liver dysfunction
  • • Severe kidney diseases
  • • Hypersensitivity or allergy to drug components

Warnings

  • • To be used under medical prescription
  • • Do not discontinue abruptly in Hepatitis B patients – may cause serious liver flare-ups

Important Monitoring Considerations

  • • Lactic acidosis
  • • Liver function – elevated liver enzymes
  • • Kidney functions
  • • Viral loads (HIV, HBV)
  • • Bone health

Drug interactions

  • • Anticonvulsants
  • • Statins
  • • Antifungals
  • • Anti-tubercular
  • • NSAIDs and other nephrology drugs

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