Emtricitable-tenofovir-alafenamide

Emtricitabine-Tenofovir-Alafenamide

Classification – HIV Medicine

Emtricitabine –Tenofovir combination?

It is a fixed-dose combination used for HIV treatment, significantly lowering viral count.

Uses

• HIV-1 treatment
• HIV-1 prophylaxis

How does it work?

It inhibits the conversion of RNA to DNA. Stops viral replication and multiplication.

Benefits

• Significantly lowers viral load
• Improves immunity
• Inhibit transmission
• Reduce the chances of developing resistance
• Reduced kidney and bone side effects
• Also effective against HBV, offering dual protection

Common side effects

• Nausea
• Weakness
• GIT upset
• Skin rashes
• Lightheadedness

Serious side effects

• Lactic acid buildup – shortness of breath
• Fluid retention – swelling of legs
• Inflammation in the liver – yellowish discoloration of urine or skin
• Loss of bone mineral density
• Anaphylaxis
• Risk of infections
• Kidney impairment

Precautions

To be used cautiously in –

• Liver diseases
• Kidney impairment
• Co-infections Hepatitis B
• Pregnant and lactating women

Contraindications

• Severe liver dysfunction
• Severe kidney diseases
• Hypersensitivity or allergy to drug components

Warnings

• To be used under medical prescription
• Do not discontinue abruptly in Hepatitis B patients – may cause serious liver flare-ups

Important Monitoring Considerations

• Lactic acidosis
• Liver function – elevated liver enzymes
• Kidney functions
• Viral loads (HIV, HBV)
• Bone health

Drug interactions

• Anticonvulsants
• Statins
• Antifungals
• Anti-tubercular
• NSAIDs and other nephrology drugs

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