Hydroxyurea

Hydroxyurea 500 Mg

• Classification -Anticancer Medicine

Hydroxyurea?

An oncology treatment widely used for blood cancer, bone marrow cancer, and various solid tumors.

Uses of Hydroxyurea -

• Resistant Chronic Myeloid Leukemia
• Melanoma
• Recurrent and Metastatic Carcinoma of the Ovary
• Head and neck cancer
• Sickle cell anemia
• Thrombocythemia

Working of Hydroxyurea-

• Inhibit the cancer enzymes, causing cell growth.
• Inhibits DNA synthesis.
• Causes Apoptosis, cancer cell death

Common side effects

• Nausea,
• Vomiting,
• Thrombopenia,
• Fatigue,
• Neutropenia

Serious side-effects

• Bone marrow suppression
• Infection risk
• Skin inflammation and rashes
• Risk of secondary malignancies
• Liver dysfunctions
• Kidney dysfunctions

Contraindications

Not to be used in patients with prior hypersensitivity to the drug or its excipients.

• Breastfeeding mothers
• Pregnant women

Precautions

• To be cautiously used in -
• Renal insufficient patients
• Bleeding disorders
• Liver disorders
• Kidney disorders
• Immune-compromised individuals
• Adjuvant to other therapies - radiation therapy
• Chronic ulcers

Toxicities

Hydroxyurea causes dose-dependent systemic toxicities.

• Bone marrow suppression causing thrombocytopenia, leukopenia
• Oral ulcers and mucositis.
• Shortness of breath, cough, pulmonary fibrosis
• Hyperpigmentation and skin ulcers

Warnings

• It is a prescription drug to be used under medical supervision only

Important safety and monitoring information

• Hydroxyurea is generally well tolerated, but requires regular monitoring for -
• Blood functions,
• Infections,
• Kidney functions
• Skin changes
• Liver functions

Gandhi Medicos - The leading oncology care platform

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It is the global leading anticancer medicine distributor, wholesaler serving leading hospitals, cancer care settings, and the top oncologists.

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