Ketoconazole

Classification -Antifungal Medicine

Ketoconazole- 200 mg?

It is used for various systemic fungal infections and yeast infections.

Uses -

Systemic fungal infections

Mucocutaneous candidiasis

Tinea infections

Dermatitis

Deep-seated fungal infections

Psoriasis, caused by a fungal infection

Working of Ketoconazole -

Breaks the fungal cell membrane integrity.

Causes fungal cell death.

Common Side Effects -

Nausea

Vomiting

Diarrhea

Fatigue

Stomach ache

Severe Side Effects -

Painful skin rashes

Menstrual irregularities

Gynecomastia

Sexual dysfunction

Arrhythmia

Suppression of the adrenal glands

Liver dysfunction

Jaundice

Electrolyte imbalance

Toxicities:

Liver toxicity

Adrenal insufficiency

Arrhythmia

QT prolongation

Precautions:

To be used cautiously in patients with

Any heart problem

Liver disorders

Alcohol abuse

Achlorhydra

Contraindications

Not to be used in patients -

Hypersensitive or allergic to the drug composition.

Breastfeeding mothers

Pregnant women

Warning

To be used under medical prescription only

Important Safety and Monitoring Information

Regularly monitor-

Liver function

Heart rhythms and

Hormonal functions

Drug interactions

Ketoconazole should be used with extreme caution with

Cholesterol medicines- statins, fibrates

Anticoagulants- Warfarin, Heparins

Cardiovascular drugs-beta blockers ,calcium channel blocker

Antihypertensive- diuretics , ACE ace inhibitors

Immunosuppressant- corticosteroids

HIV- DDA

Antipsychotics- antidepressants

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