L-Asparaginase

Classification - Anti-cancer medicine

L-Asparaginase?

Asparaginase is an enzyme used as an anticancer medicine that blocks the cancer processes of growth and division.

It is the targeted therapy drug that kills the viable cells without harming the normal cells.

It is used to achieve complete remission in adults and pediatric patients.

Uses of Asparaginase -

Lymphoblastic Leukemia (acute) / lymphoma

Working of Asparaginase-

Break down the L-asparagine enzyme

Cancer cell starvation

Apoptosis and cell death

Common side effects of Asparaginase

Increases infection risks

Blood clots

Diarrheas

Weight loss

Loss of appetite

High albumin levels, bilirubin levels

Edema

Lowered blood pressure

Abdominal pain

Serious Side-effects

Pancreatic bleeding

Thromboembolism- clots and strokes

Bone marrow suppression - thrombocytopenia

Shortness of breath

Toxicities

Hepatotoxicity

Thrombosis and bleeding

Pancreatitis

Contraindications

Not to be used in hypersensitivity to drug components.

Breastfeeding mothers

Pregnant women

Precautions

To be used cautiously in patients with

Heart disease

Low blood count

Liver disease

Pancreatitis

Warnings

To be used under medical supervision only, do not mix dextrose-containing solutions (incompatibility).

Storage:

Store at 2-8 degrees Celsius

Reconstitute the solution just before administration.

Important safety and monitoring information

Regular monitoring is required for liver functions, pancreatic enzymes, blood coagulation, and sugar levels.

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