Ledipasvir 90 mg and Sofosbuvir 400 mg
Ledipasvir- 90mg + Sofosbuvir- 400mg
Composition
- Ledipasvir – 90 mg
- Sofosbuvir – 400 mg
Classification: Hepatitis C Medicine
Ledipasvir, Sofosbuvir combination?
It is a combination of drug therapy used for hepatitis C infection for genotypes -1, 4, 5, and 6.
Uses
- Chronic hepatitis C
- Post liver transplant hepatitis C prevention
Working of Ledipasvir and Sofosbuvir combination
The combination of two drugs inhibits two different enzymes and offers a potential blockade for viral replication.
Common Side Effects
- Tiredness
- Insomnia
- Diarrhea
- Nausea
- Headache
- Irritable mood
Serious Side Effects
- Slow heart rate
- Skin rashes
- Swelling
- Difficulty in breathing
- Reactivation of hepatitis B
- Liver dysfunction
- Reduce hemoglobin count when used with ribavirin
Benefits
- Can be used in pediatric patients
- Can be used in compensated cirrhosis
- Can be used post-liver transplant
- Well-tolerated
- Safe and effective in HIV co-infections
Precautions
To be used cautiously in patients
- Hepatitis B co-infections
- HIV co-infections
- Heart disorders
- Liver disorders
- Pregnant and breastfeeding women
- In children
- Kidney disorders
Contraindications
- Allergy or hypersensitivity to drug components
- End-stage renal disease
- Combined use with Amiodarone
- In pregnancy, when combined with ribavirin
Warning
It is a prescription drug to be taken under medical supervision only.
Important Safety and Monitoring Information
- Regular monitoring of hepatic functions
- Renal functions
- Cardiac functions
- Co-infections
- Neuropsychiatric adverse reactions
- Drug interactions – Ribavirin and Amiodarone
- Not to be used alone for HCV infections
Drug Interactions
- Ribavirin
- Antacids
- Rifampin
- Histamine blockers
- Proton pump inhibitors
- Anticoagulants
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Formulations based on "Ledipasvir 90 mg and Sofosbuvir 400 mg" (5)
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