Pirfenidone

Classification: Respiratory Medicine

What is Pirfenidone?

It is an antifibrotic drug used against scarring of the lung tissues.

Uses

  • • Pulmonary Fibrosis
  • • Liver fibrosis
  • • Systemic sclerosis

Working of Pirfenidone

  • • It reduces inflammation and prevents lung scars.

Benefits

  • • It’s well tolerated
  • • Slows down lung scarring
  • • Delays disease progression
  • • Preserves Lung capacity

Common Side Effects

  • • Nausea
  • • Diarrhea
  • • Skin rashes due to photosensitivity

Serious Side Effects

  • • Severe hepatic dysfunction
  • • Jaundice
  • • Gastric bleeding
  • • Tiredness
  • • Blistering or peeling of skin

Precautions

To be used cautiously in patients with –

  • • Liver disorders
  • • Renal disorders
  • • Elderly patients
  • • Pre-existing skin infections
  • • Smoking
  • • Alcohol
  • • Gastrointestinal disorders

Contraindications

  • • Severe Liver dysfunction
  • • Severe renal impairment
  • • Allergy to drug components

Warnings

To be used as prescribed by the doctor.

Important safety and monitoring information

Regularly monitor –

  • • Total blood count
  • • Liver functions
  • • Infection risks
  • • Heart functions
  • • Neuropathy

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