Ribavirin
Classification: Hepatitis C medicines
What is Ribavirin?
Its antiviral nature is used against Hepatitis C treatment.
Uses of Ribavirin
- • Chronic Hepatitis C
- • Respiratory Viral Disease
Working of Ribavirin
- • It changes the viral cell integrity.
- • Inhibits both RNA and DNA multiplication and replication.
Benefits
- • It can be used in combination with other antivirals.
- • Boost the effectiveness of other antivirals.
- • Lowers the risk of relapse
- • Effective against various viral RNA /DNA
- • Can be used for Respiratory viruses in infants and immunocompromised individuals
Common Side Effects
- • Nausea
- • Dizziness
- • Headache
- • Digestive issues
- • Tiredness
- • Diarrhea
Serious Side Effects
- • Destroying red blood cells causes severe Anemia.
- • Pancreatitis
- • Hepatic toxicity- Avoid alcohol while treatment
- • Neuropsychiatric condition- depression, confusion
- • Cardiac toxicity – heart attack, strokes
- • Suppresses the immune system
Precautions
To be cautiously used in patients with –
- • Liver disorders
- • Kidney disorder
- • Anemic
- • Severe psychiatric illness
- • Autoimmune disease
- • Severe heart disease
- • And co-administration with another drug like zivoduvine.
Contraindications
- • Allergy or hypersensitivity to any drug component.
- • Breastfeeding mothers
- • Pregnant women
Warning
Take only when recommended by the doctor.
Important Safety and Monitoring Information
Regular monitoring of –
- • Hepatic functions
- • Renal functions
- • Cardiac functions
- • Co-infections, and neuropsychiatric adverse reactions.
Drug interactions –
- • Zidovudin, Didanosine, Azathioprin – It increases the risk of a fall in RBC count and lactic acidosis.
- • Antacids – They may impair antacid absorption.
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