Lopinavir + Ritonavir

Lopinavir / Ritonavir

Classification

• - HIV medicine

Why Lopinavir/ Ritonavir combination?

A fixed-dose combination is widely used against HIV infection. Lopinavir induces viral cell death, and ritonavir prolongs its effect.

Uses of Lopinavir/Ritonavir

HIV infection

Working of the lopinavir-ritonavir combination-

It inhibits the HIV protease enzyme. Inhibit cell multiplication and replication. Causes viral cell death.

Benefits

It significantly lowers the viral load. Improves immune function Increases CD-4 cell count

Common side effects

Nausea Vomiting Tiredness Increase cholesterol levels Increase blood sugar Headache Rash, itchiness

Serious side effects

Hepatotoxicity - elevated liver enzymes QT prolongation Severe heart complications Lactic acid buildup Pancreatitis Allergic reaction

Precautions:

To be used cautiously in - Severe liver disorders Renal impairment Cardiovascular diseases High cholesterol levels Pancreatitis Bleeding disorders Elderly Children Pregnant and breastfeeding women

Important monitoring considerations

Liver functions Kidney functions Blood sugar, blood pressure Signs of pancreatitis

Drug interactions

Dose adjustment is required when used with - Anticonvulsant drugs Cardiovascular drugs Antihypertensive Anti-fungal and Anti-tubercular drugs Cholesterol-lowering medicines - statins Various herbal formulations - ergotamine derivatives Sedatives

Contraindications

Severe liver dysfunction. Hypersensitivity or allergic reaction to the drug or its excipients.

Warnings

To be used under medical prescription. Do not stop in Hepatitis B patients.

Gandhi Medicos - Trusted Pharmacy for HIV Medicine

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