Daclatasvir + Sofosbuvir

Daclatasvir

Clasification : Hepatitis C medicine

What is Daclatasvir?

It is Hepatitis C medicine used for the treatment of chronic hepatitis c.

How does it work?

It causes conformational changes in viral cell structure.

It inhibits viral cell replication and assembly

Uses of Daclatasvir -

Chronic Hepatitis C

Against HCV strains -1-3 and others

HCV infections- it is used in combination, not to be used alone.

How does Daclatasvir work?

NA5A protein inhibition

It inhibits viral replication, assembly, and release

Block new viral cell formation

Benefits -

Rapidly reduces viral load

Well tolerated, fewer side effects

Shorter treatment duration

Broad spectrum of activity (genotypes 1-3)

Safe in HIV co-infections

Can be used in compensated cirrhosis

Can be used post-liver transplant

Less risk of the development of resistance

Common Side Effects

Nausea, dizziness, headache, digestive issues, tiredness, diarrhea

Severe Side Effects

Severe fall in RBC count when used with Ribavirin

Anxiety, confusion

Elevated liver enzymes, or hepatic decompensating in advanced-stage liver disorder

Low heart rate when used with Amiodarone

Precautions

To be used cautiously in patients -

Heart disorder

Decompensated liver cirrhosis

HIV co-infections

Drug interactions

Contraindications

Not to be used if any previous allergy or hypersensitivity to Daclatasvir, or any excipients.

Breastfeeding mothers

Pregnant women

Warning

To be taken when prescribed under the supervision of a specialist.

Important Safety and Monitoring Information

Regular monitoring of hepatic functions, renal functions, cardiac functions, co-infections,

Drug interactions - Ribavarin and Amiodarone

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