Ledipasvir + Sofosbuvir

Sofosbuvir + Ledipasvir

Classification: Hepatitis C Medicine

Sofosbuvir + Ledipasvir combination –

Trusted combination of antiviral drugs effective against Hepatitis C genotypes 1,4,5,6.

Can be used in cirrhosis (both compensated and decompensated).

Can be used in HIV co-infections.

In children > 3 years

Can be used post-liver transplant

Uses

Chronic Hepatitis C

HCV-HIV co-infections

Working of Sofosbuvir and Ledipasvir

It inhibits viral cell replication by inhibiting two different protein polymerases, offering potent viral suppression.

Benefits

Short-term treatment

High cure rates

Low resistance risk

Well tolerated

Reduces liver damage

Common Side Effects

Nausea

Dizziness

Headache

Digestive issues

Tiredness

Muscle pain

Joint pain

Serious Side Effects

Severe Bradycardia (when taken with amiodarone)

Causes Hepatitis B reactivation

Severe liver failure

Severe anemia upon use with ribavirin

Depression, mood swings, and confusion

Precautions

To be used cautiously in patients with:

Kidney disorders

Cardiac disorders

Liver disorder

Hepatitis B co-infections

HIV co-infection

When used with ribavirin and amiodarone

Contraindications

Allergy or hypersensitivity to drug components

Breastfeeding mothers

Pregnant women

Should not be used with Amiodarone, Antacids, and Proton pump inhibitors.

Warning

To be taken under the instructions of the doctor.

Important Safety and Monitoring Information

Regular monitoring of hepatic, renal, and cardiac functions

Co-infections

Neuropsychiatric adverse reactions

Drug interactions – Ribavirin and Amiodarone

Not to be used alone for HCV infections

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