Tacrolimus 1mg

Classification – Organ Transplant Medicine

What is Tacrolimus?

Tacrolimus is an organ transplant medicine, widely used for post-transplant care and prophylaxis of organ rejection.

Best-selling Transplant Medicine – Xgraf -1

Uses of Tacrolimus

  • • Prophylaxis for organ transplant
  • • Post-transplant therapy
  • • Kidney transplant
  • • Liver transplant
  • • Heart transplant

Working of Tacrolimus

It suppresses the activity of T cells and lowers the immune response.

Accepts the organ transplants.

Benefits

  • • Faster onset
  • • Potent immune-suppression
  • • Long-term graft survival

Common Side Effects

  • • Increases creatinine
  • • Skin rashes
  • • Headache
  • • GIT upset
  • • Nausea
  • • Diarrhea
  • • High calcium levels
  • • Low potassium levels
  • • Tiredness

Serious Side Effects

  • • Renal toxicity
  • • Severe infections
  • • Seizures, encephalopathy
  • • Bone marrow suppression
  • • Metabolic dysfunctions
  • • Cardiovascular side effects – arrhythmias, high blood pressure
  • • Lymph proliferative disorder (PTLD)

Precautions

To be used cautiously in:

  • • Elderly Patients
  • • Bleeding disorders
  • • Liver disorders
  • • Kidney diseases
  • • Active infections – HIV, Hepatitis
  • • Diabetics
  • • Hypertension patients
  • • Neurological disorders

Safety Instructions

  • • Maintain contraception during the treatment
  • • Avoid live vaccines (MMR, Varicella) due to a compromised immune system

Contraindications

  • • Pregnant women and breastfeeding mothers
  • • Hypersensitivity or allergic reaction to the drug or its excipients

Warnings

To be used under medical prescription only.

Drug Interactions

  • • Antivirals
  • • Antibiotics
  • • TB medicines
  • • Other immune suppressants
  • • Cardiovascular drugs – calcium channel blockers
  • • Antifungals
  • • Grapefruit juice

Important Monitoring Considerations

  • • Total blood count
  • • Liver and kidney functions
  • • Neurological functions
  • • Blood pressure, blood glucose
  • • Cardiac functions
  • • Dose monitoring is required

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