Tacrolimus 2mg

Classification: Organ Transplant Medicine

What is Tacrolimus 2mg?

Tacrolimus involves lifelong use after the organ transplant surgery in order to protect the organ.

Top-selling Transplant Medicine: Xgraf -1

Uses of Tacrolimus 2mg

  • • Prophylaxis for organ transplant.
  • • Post-transplant therapy
  • • Kidney transplant
  • • Liver transplant
  • • Heart transplant

Working of Tacrolimus 2mg

It inhibits or lowers the activity of the immune cells and aids in organ protection.

Benefits of Tacrolimus 2mg

  • • Faster onset
  • • Potent immune-suppression
  • • Long-term graft survival

Common Side Effects

  • • Increases creatinine
  • • Skin rashes
  • • Headache
  • • GIT upset
  • • Nausea
  • • Diarrhea
  • • High calcium levels
  • • Low potassium levels
  • • Tiredness

Serious Side Effects

  • • Renal toxicity
  • • Severe infections
  • • Seizures, encephalopathy
  • • Bone marrow suppression
  • • Metabolic dysfunctions
  • • Cardiovascular side effects
  • • Arrhythmias, high blood pressure
  • • Lymph proliferative disorder (PTLD)

Precautions:

To be used cautiously in–

  • • Elderly Patients
  • • Bleeding disorders
  • • Liver disorders
  • • Kidney diseases
  • • Active infections- HIV, Hepatitis
  • • Diabetics
  • • Hypertension patients
  • • Neurological disorders

Safety instructions

  • • Maintain contraception during the treatment.
  • • Avoid vaccines (MMR, Varicella) that contain live virus.

Contraindications

  • • Pregnant women
  • • Breastfeeding mothers.
  • • Allergy to drug components

Warnings

To be used under medical prescription.

Drug Interactions

  • • Antiviral
  • • Antibiotics
  • • TB medicines
  • • And other immune suppressants
  • • Cardiovascular drugs –calcium channel blockers
  • • Antifungal
  • • Grapefruit juice

Important Monitoring Considerations

Monitor for –

  • • Total blood count
  • • Liver and kidney functions
  • • Neurological functions
  • • Blood pressure, blood glucose
  • • Cardiac functions
  • • Dose Monitoring is required.

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