Daclatasvir

Classification: Hepatitis C Medicine

What is Daclatasvir?

It is a Hepatitis C medicine used for the treatment of chronic hepatitis C.

How does it work?

  • It causes conformational changes in viral cell structure.
  • It inhibits viral cell replication and assembly.

Uses of Daclatasvir

  • Chronic Hepatitis C
  • Against HCV strains -1-3 and others
  • HCV infections – it is used in combination, not to be used alone.

How does Daclatasvir work?

  • NA5A protein inhibition
  • It inhibits viral replication, assembly, and release
  • Blocks new viral cell formation

Benefits

  • Rapidly reduces viral load
  • Well tolerated, fewer side effects
  • Shorter treatment duration
  • Broad spectrum of activity (genotypes 1-3)
  • Safe in HIV co-infections
  • Can be used in compensated cirrhosis
  • Can be used post-liver transplant
  • Less risk of the development of resistance

Common Side Effects

  • Nausea
  • Dizziness
  • Headache
  • Digestive issues
  • Tiredness
  • Diarrhea

Severe Side Effects

  • Severe fall in RBC count when used with Ribavirin
  • Anxiety, confusion
  • Elevated liver enzymes, or hepatic decompensating in advanced-stage liver disorder
  • Low heart rate when used with Amiodarone

Precautions

To be used cautiously in patients –

  • Heart disorder
  • Decompensated liver cirrhosis
  • HIV co-infections
  • Drug interactions

Contraindications

  • Not to be used if any previous allergy or hypersensitivity to Daclatasvir, or any excipients
  • Breastfeeding mothers
  • Pregnant women

Warning

To be taken when prescribed under the supervision of a specialist.

Important Safety and Monitoring Information

  • Regular monitoring of hepatic functions
  • Renal functions
  • Cardiac functions
  • Co-infections

Drug interactions – Ribavarin and Amiodarone

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