Fulvestrant

Classification - Anticancer Medicine

Fulvestrant?

It is an anticancer medicine widely used for breast cancer in post-menopausal women.

Uses -

HER-2 positive breast cancer

HER-2 negative breast cancer

Breast cancer that is resistant to endocrine therapy.

How does Fulvestrant work?

Selective Estrogen Receptor Antagonist.

It inhibits estrogen hormone, which causes cancer cells to grow.

Stops cancer cell growth.

Shrink the tumor.

Benefits

As a preferred second-line option.

Longer progression-free survival.

Directly downregulate the receptor, offering complete blockade.

Has better tolerance and a favorable safety profile.

Precautions -

Carefully administer to patients with -

Blood disorders,

Hypersensitive individuals,

Hepatic impairment,

Children, pregnant or lactating mothers.

Elderly patients who are at risk of osteoporosis.

Vitamin D or Calcium deficiency

Adverse drug effects

Risk of bleeding,

Sore throat,

Mouth sores,

Upset stomach,

Nausea,

Loss of appetite,

Headache, and

Tiredness.

Flushing or redness of the skin at the site of injection.

Serious side effects -

Hepatotoxicity - yellow coloration of urine, jaundice, hepatitis

Pulmonary embolism, blood clots

Severe necrosis

Gastrointestinal perforation, bleeding

Fracture or risk of bone demineralization

Important Safety and Monitoring Information

To monitor regularly during the therapy

Total blood count

Hepatic functions

Kidney functions

Local tissue necrosis

Risks of bleeding

Thromboembolic events

Contraindications -

Allergy or hypersensitivity to the drug components.

Breastfeeding mothers

Pregnant women

Warning:

To be used under medical supervision, an oncologist specialist.

Storage

It is to be stored at 2-8 degrees Celsius, protected from light.

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