Gemcitabine Chemotherapy for Breast, Lung, Pancreatic & Ovarian Cancer

Gemcitabine

Classification: Anticancer

Gemcitabine?

It is an anticancer medicine, listed as an essential medicine by the WHO.

Uses of Gemcitabine

Advanced-stage ovarian cancer

• Breast cancers
• Pancreatic cancer
• Lung cancer
• Bladder cancer

How Does it Work?

Gemcitabine mimics cancer DNA bases, inhibiting the chain elongation process.
It stops cancer cell DNA multiplication or growth, causing cell death.

Common Side Effects

• Nausea
• GIT upset – diarrhea, constipation
• Skin rashes
• Low platelets
• Anemia
• Risk of infections

Serious Side Effects

• Respiratory dysfunction
• Hepatic toxicity – elevated liver enzymes
• Bleeding
• Shortness of breath
• Fast irregular heartbeat
• Change in urine color and volume

Precautions

To be cautiously used in:

• Renal dysfunction
• Liver disorder
• Elderly patients
• Respiratory disorders
• Radiation therapy history

Contraindications

• Allergy or hypersensitivity to gemcitabine or any drug components
• Breastfeeding mothers
• Pregnant women

Warnings

To be used under the supervision of a practitioner or doctor.

Important Safety and Monitoring Information

• Regularly monitor blood count, hepatic, manage infection risks, respiratory functions, and renal functions.
• Check for fluid retention, hypotension
• Capillary leak and immediate swelling

Storage

• To be stored at 2-8 degrees Celsius.
• Protect from light.

Administration Instructions

• To be administered as a slow IV infusion.
• To be used immediately after reconstitution.

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