Soranib Tablet

Soranib 200 mg

It is known to fight against the tumors of kidney, liver and thyroid. Scientifically, Soranib 200 mg (sorafenib) has anti-tumor properties like,

1. Reduction of blood flow to the tumor cells (tumor angiogenesis)
2. Stopping the growth of tumor cells (tumor-cell proliferation)
3. Speeding up the process of self-destruction in those cells (Apoptosis)

Soranib 200 mg (sorafenib) is utilized in patients suffering from different cancer types namely

• Kidney [Advanced Renal cell carcinoma (RCC)]
• Liver [Unresectable hepatocellular carcinoma (HCC)]
• Thyroid [Locally advanced and metastatic differentiated thyroid carcinoma (DTC)]

Dosage, Mode of Action, and Administration of Soranib 200 mg (sorafenib):

Soranib 200 mg (Sorafenib) is given orally with the recommended dosage of 400 mg (2×200 mg) twice daily without food (Total dose: 800 mg in one day). It is taken at least 1 hour before or 2 hours after a meal. Once sorafenib enters our system, more than 38-49% of the tablet is absorbed (bio-available) in the body which is further metabolized in the liver. It is known for slowing down the activities of multiple proteins/enzymes (intracellular and cell surface kinases) that are involved in the growth of cancerous cells. Lastly, sorafenib is completely expelled from the body within 14 days.

Dose reduction in DTC patients for toxicity:

When should Soranib 200 mg (sorafenib) be avoided or used cautiously?

• If patients are suffering from heart problems, chest pain, or have high blood pressure
• If patients have undergone any surgical procedures recently
• If they have bleeding complications, abnormal levels of magnesium, potassium, and calcium
• If they are pregnant or planning to get pregnant
• In the case of stomach and intestinal complications, sorafenib should be immediately stopped
• If liver functions are abnormal (elevated levels of transaminase enzymes)
• If ECGs and electrolytes get overall increased (ventricular arrhythmias)
• Decreased or discontinued in patients with severe skin reactions (Steven-Johnson syndrome or toxic epidermal necrolysis)

Possible side-effects of Soranib 200 mg (sorafenib):

Most common ones are:

• Nausea
• Abdominal/ stomach pain
• Loss of appetite
• Weight loss
• Diarrhoea
• Tiredness
• Hand, foot or skin rashes or reactions

Serious side-effects are:

Heart attack/failure: Patients should be immediately checked for chest pain, shortness of breath, increased heartbeat, nausea, swelling in the lower part of the legs, and high sweating

Increased bleeding: A most common side-effect of sorafenib. Doctors should be immediately informed if patients are seen with any signs of bleeding

Soranib is also available in these countries: (South East Asia, South America, Eastern Europe, Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Macedonia, Poland, Republic of Kosovo, Republic of Moldova, Romania, Russia, Serbia, Slovak Republic, Slovenia, Malaysia, Indonesia, Philippines, Venezuela and Korea.) and many more…