Abirakast 500mg Tablet

Abiraterone 500mg Tablet  is a recently discovered hormonal therapy for adult male patients suffering from prostate cancer. Abiraterone 500mg Tablet is an oral drug which inhibits the action of proteins (CYP17A1 enzyme) that are responsible for producing a male hormone called testosterone. Abiraterone 500mg Tablet targets the excessive production of testosterone as prostate cancer cells require these hormones to flourish. Abiraterone is specifically used in patients with prostate cancer,

• Where other chemotherapy options (docetaxel) did not work (metastatic castration-resistant prostate cancer)
• In adults with mild symptoms or no symptoms where chemotherapy has not been given yet or other hormonal therapies (androgen deprivation therapy) do not work

Peculiar advantages of Abiraterone 500mg Tablet

• It keeps prostate cancer under control
• Increases duration of life-span
• Delays or rectifies common symptoms such as pain and tiredness

Abiraterone is used in combination with prednisone (a drug used to suppress the immune system for reducing inflammation). When used together, abiraterone impart advantages such as,

• Reduction of hypertension as a side-effect
• Lowering the production of antigen that stimulates prostate cancer
• Induction of hunger for a stable diet

Administration of Abiraterone 500mg Tablet:

Abiraterone acetate is given orally in 1000 mg concentrations i.e. 4 tablets of 250 mg once a day. Along with abiraterone, prednisone 5 mg is also given twice daily. Once administered, abiraterone gets readily-absorbed (bioavailable) within 2 hours throughout the body. Once abiraterone completes its action, approximately 55% of the drug is expelled from the body in between 5-14 hours. Abiraterone is recommended on an empty stomach. Consumption of food should be completely avoided for at least 2 hours prior and 1 hour after the dose. Avoid crushing or swallowing tablets without water. It is equally important to avoid grapefruit juice as it triggers unwanted side-effects.

When should Abiraterone 500mg Tablet be avoided or used cautiously?

• If patients were previously suffering from heart diseases or failure
• If patients have hypertension or arrhythmia, carry out blood tests monthly
• In patients have stress, steroid hormones used for retention of water and production of potassium are not produced (adrenocortical insufficiency), in that case, corticosteroid drugs (prednisone) are recommended
• If patients have complications of the liver causing an increase in the production of unwanted liver proteins (hepatoxicity)

Most common side-effects of Abiraterone 500mg Tablet:

• Unwanted swelling (edema)
• Tiredness
• Discomfort in joints and muscles
• Problems in the stomach like diarrhea, indigestion and vomiting
• Shortness of breath (dyspnea) or infection in the upper respiratory tract
• Feeling uncomfortably hot (Hot flush)
• Cough
• Urinary tract infection

Laboratory side-effects of Abiraterone 500mg Tablet:

• Low levels of potassium (hypokalemia) and phosphate (hypophosphatemia)
• Weakness caused due to lack of hemoglobin in the blood (anemia)
• High levels of fat molecules (triglycerides) (hypertriglyceridemia), cholesterol (hypercholesterolemia), and sugars (hyperglycemia)

Augmented levels of proteins/enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase

Note: We are also exporting to countries: Malaysia, Indonesia, Philippines, Venezuela and Korea.