Velpanat

Description

Velpanat (Sofosbuvir 400 mg + Velpatasvir 100 mg) is a combinational anti-Hepatitis C drug used in patients with genotype 1 to 6. The combined inhibitory action of Sofosbuvir 400 mg and Velpatasvir 100 mg, allows 93-99% of overall response rate against HCV cells.

The dosage of Velpanat consists of 400 mg of sofosbuvir and 100 mg of velpatasvir combined in a single tablet. The tablet is taken orally once daily with or without food. In situations where the patients are at higher risk of liver disease, ribavirin is also added for a constant response.

Velpanat (Sofosbuvir + Velpatasvir) has one of the highest sustained viral response (SVR) amongst combined anti-HCV agents. However, the SVR differs based on the type of liver disease associated with HCV.

Note:

• •  Compensated cirrhosis: Cirrhosis (scarring of the liver) with a functional system
• •  Decompensated cirrhosis: Cirrhosis without a functional system

What should be stated to the doctor before taking Velpanat (Sofosbuvir + Velpatasvir)?

• •  About any complications associated with liver and kidney
• •  If you are on dialysis therapy
• •  If you have any mental problems like stress or anxiety
• •  Heart problems like increased heartbeats (bradycardia)
• •  Are pregnant or planning for pregnancy (Females taking the drug should avoid becoming pregnant during treatment or 6 months after stopping the treatment)
• •  About all the medicines that patients are consuming in the present
• •  History or current infection related to Hepatis B virus

Other properties of Velpanat (Sofosbuvir + Velpatasvir):

Sofosbuvir 400 mg:

• •  Absorbed within 30 minutes to 2 hours
• •  Binding with viral cells is 61% to 65%
• •  Metabolized in liver
• •  Inhibits, NS5B protein which carries out reproduction in daughter viruses
• •  Takes around 40 minutes to 27 hours for 50% of excretion

Velpatasvir 100 mg:

• •  Absorbed within 3 hours
• •  Binding with viral cells is 99%
• •  Metabolized in liver
• •  Inhibits, NS5A protein which carries out reproduction in daughter viruses
• •  Takes around 15 hours for 50% of excretion
• •  Allows a barrier for reducing chances of resistance to both drugs

Side-effects of Velpanat (Sofosbuvir + Velpatasvir):

Side-effects in HCV patients without cirrhosis or cirrhosis with a functional system:

• •  Nausea
• •  Physical weakness (Asthenia)
• •  Lack of sleep (Insomnia)
• •  Headache
• •  Tiredness

Side-effects in HCV patients with cirrhosis and an unfunctional system:

• •  Diarrhea
• •  Low count of red blood cells (RBCs) (Anemia)
• •  Lack of sleep
• •  Headache
• •  Tiredness
• •  Nausea

Note: These are not all possible side-effects of Velpanat (sofosbuvir + velpatasvir), please ask your doctor for more information regarding the same.