Carboplatin – 450mg

Classification: Anticancer medicine

Carboplatin?

It is used as a cancer medicine for various tumors and cancers.

Uses of Carboplatin

  • • Ovarian cancers
  • • Endometrial cancer
  • • Head and Neck Cancer
  • • Palliative care for recurrent cancer
  • • Cancer of the esophagus
  • • Non-small cell lung cancer
  • • Lung cancer
  • • Breast cancer

Working of Carboplatin

It causes cancer cell death by crosslinking DNA strands.

Common Side Effects

  • • Alopecia
  • • Weakness
  • • Nausea
  • • Diarrhea
  • • Kidney dysfunctions
  • • Liver dysfunctions
  • • Dehydration
  • • Anemia
  • • Risk of infections

Serious Side Effects

  • • Myelosuppression
  • • Hepatic toxicity
  • • Renal toxicity
  • • Otto-toxicity

Precautions

To be used cautiously in:

  • • Renal disorders
  • • Liver disease
  • • Bleeding disorders
  • • Hearing issues
  • • Elderly patients
  • • Bone marrow suppression

Contraindications

  • • Hypersensitivity to carboplatin or other platinum compounds
  • • Bone marrow suppression
  • • Breastfeeding mothers
  • • Pregnant women

Important Handling Instructions

  • • Carboplatin harms living cells; wear gloves when handling.
  • • Wash immediately if in contact with skin or mucosa.
  • • Do not use aluminum needles or IV sets – loss of potency may occur.

Warnings

To be used under a doctor’s supervision.

Important Monitoring

  • • It causes dose-dependent bone marrow suppression
  • • Peripheral blood counts
  • • Renal functions
  • • Liver functions
  • • Electrolyte balance
  • • Ear functions

Storage

  • • Store at 2-8 degrees Celsius
  • • Protect it from light.

Administration Instructions

  • • To be administered via IV infusion only (15–60 minutes).
  • • To be used immediately after reconstitution.

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Highly prescribed and top-selling carboplatin formulation – Carbokast-450 mg