Sofosbuvir + Velpatasvir
Composition: Sofosbuvir – 400mg, Velpatasvir – 100 mg
Classification: Hepatitis C Medicine
What is Sofosbuvir + Velpatasvir?
It is a widely prescribed combination to achieve potent viral suppression. It is effective against all major Hepatitis C genotypes.
Sofosbuvir + Velpatasvir Uses
- • Chronic Hepatitis C
- • HCV-HIV co-infections
- • Naïve Hepatitis C treatment or /relapsed treatment
Working of Sofosbuvir + Velpatasvir?
It mimics natural nucleosides and inhibits RNA replication and multiplication.
Benefits of Sofosbuvir + Velpatasvir combination
- • Pan genotypic coverage (effective against all Hepatitis C strains).
- • Shorter treatment duration
- • It can be used in HIV co-infections.
- • Can be used with ribavirin
- • Effective in advanced liver diseases
- • In children > 3 years
- • Post liver transplant
- • Low resistance risk
Sofosbuvir + Velpatasvir Side Effects
- • Nausea
- • Dizziness
- • Headache
- • Digestive issues
- • Tiredness
- • Diarrhea
Severe Side Effects
- • Severe Bradycardia (when taken with amiodarone)
- • Causes Hepatitis B reactivation.
- • Severe liver failure.
- • Severe anemia upon use with ribavirin.
- • Depression, mood swings, and confusion
Precautions using Sofosbuvir + Velpatasvir combination
To be used cautiously in patients
- • Kidney disorders
- • Liver disorder
 Heart disorders
- • Hepatitis B co-infections – cause reactivation
- • HIV co-infection
- • When used in combination with ribavirin and amiodarone
Contraindications
- • Hypersensitive reaction to drug components.
- • Breastfeeding and Pregnant Women
Warnings
To be used when prescribed by a medical practitioner.
Not to be used alone for HCV infections.
Important Safety and Monitoring Information
- • Regular monitoring of hepatic functions
- • Renal functions
- • Cardiac functions
- • Co-infections
- • Neuropsychiatric adverse reactions
Drug Interactions
- • Ribavirin and Amiodarone
- • Anticonvulsant
- • Antivirals
- • Cardiovascular medicines
- • Hypertension medicines
- • Antacids and PPIs
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