Sofosbuvir + Velpatasvir

Composition-

Sofosbuvir - 400mg

Velpatasvir - 100 mg

Classification - Hepatitis C Medicine

Sofosbuvir + Velpatasvir?

It is a widely prescribed combination to achieve potent viral suppression. It is effective against all major Hepatitis C genotypes.

Sofosbuvir + Velpatasvir uses -

Chronic Hepatitis C

HCV-HIV co-infections

Naïve Hepatitis C treatment or /relapsed treatment

Working of Sofosbuvir+ Velpatasvir

It mimics natural nucleosides and inhibits RNA replication and multiplication.

Benefits of Sofosbuvir+ Velpatasvir combination

Pan genotypic coverage (effective against all Hepatitis C strains).

Shorter treatment duration

It can be used in HIV co-infections.

Can be used with ribavirin

Effective in advanced liver diseases

In children> 3 years

Post liver transplant

Low resistance risk

Sofosbuvir+ Velpatasvir side-effects

Nausea,

Dizziness,

Headache,

Digestive issues,

Tiredness,

Diarrhea

Severe Side Effects

Severe Bradycardia (when taken with amiodarone)

Causes Hepatitis B reactivation.

Severe liver failure.

Severe anemia upon use with ribavirin.

Depression, mood swings, and confusion

Precautions using Sofosbuvir+ Velpatasvir combination

To be used cautiously in patients

Kidney disorders

Liver disorder

Heart disorders

Hepatitis B co-infections- cause reactivation

HIV co-infection

When used in combination with ribavirin and amiodarone

Contraindications

Hypersensitive reaction to drug components.

Breastfeeding and Pregnant Women

Warning

To be used when prescribed by a medical practitioner.

Not to be used alone for HCV infections.

Important Safety and Monitoring Information

Regular monitoring of hepatic functions,

Renal functions,

Cardiac functions,

Co-infections, and

Neuropsychiatric adverse reactions.

Drug interactions -

Ribavirin and Amiodarone

Anticonvulsant

Antivirals

Cardiovascular medicines

Hypertension medicines

Antacids and PPIs

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